Search 4,372 high-resolution slide records by strain, cutting plane, age, sex, body weight, brain weight, and celloidin ID. Filter by available hippocampus or hi-resolution section images. View full-slide thumbnails, metadata, and linked hi-magnification images for each case.
Search the MBL LibraryLabeled high-resolution cross-sections of mouse brains, including developmental atlases at GD12 and GD16. Includes a step-by-step tutorial for creating your own mouse brain atlas.
View AtlasesReal-time remote access to the physical slides comprising the Mouse Brain Library. Secure user authentication and scheduling ensures reliable, responsive access. Gumbo + Aria3D client software.
Launch iScopeDetailed protocols covering brain processing, celloidin embedding, microtome sectioning, imaging, calibration, and making data available online. Includes the full MBL Training Manual.
View ProceduresA collection of high-magnification electron micrographs of the mouse optic nerve suitable for quantitative, comparative, and genetic analysis of axon number, diameter, and myelin morphology.
View MONIDSeries of brain image movies, microscope focus-through sequences, and cell identification movies in QuickTime format. Includes step-by-step tutorial videos for working with the MBL.
View MoviesMapping the Genetic Architecture of the Mouse CNS
The Mouse Brain Library (MBL) consists of high-resolution images and databases of brains from many genetically characterized strains of mice. The library contains high-resolution images (3,060 × 2,036 pixels, 25 µm per pixel) of individual slides, usually two per case.
"There are numerous uses of the MBL, but our own mission is to systematically map and characterize genes that modulate architecture of the mammalian CNS — for a complete description of our projects refer to our P20 Human Brain Project award: Informatics Center for Mouse Neurogenetics."
We are in the process of acquiring images for more than 1,500 cases, usually 8 cases per strain cut in either the horizontal or coronal planes. All sections are 30 µm-thick sections stained with cresyl violet, an aniline dye that preferentially stains RNA and DNA. Over 800 cases are currently available online.
The MBL is a resource of the Informatics Center for Mouse Neurogenetics and is funded as a Human Brain Project / Neuroinformatics program by the NIDA, NIMH, and NIAAA (P20-DA 21131).